Patients with permanent defects in gonadotrophin secretion may receive sex steroids in slowly increasing doses up to a full replacement dose, taking care that maximal growth is obtained before sex steroid administration fuses the epiphysial growth plates. The dosage of testosterone enanthate may be increased from 100mg every four weeks to 200mg and then 300mg every four weeks over a period of six to twelve months. A large dose of testosterone offered immediately may cause priapism and psychological changes, but if offered in an increasing pattern, it is easier to tolerate.
